Nov 21, 2019

Trinity Scientists Make Breakthrough in Inflammatory Disease Research

The team's findings outline outline how the protein PKM2 can act as a potential therapeutic target in the treatment of certain diseases.

Alaa AdwanContributing Writer
Ivan Rakhmanin for The University Times

A Trinity research team has revealed a new role for a particular protein in regulating immune cells involved in multiple inflammatory diseases.

The findings, reported today in Cell Metabolism, the world’s leading metabolism journal, outline how the protein PKM2 can act as a potential therapeutic target in the treatment of disorders which are stimulated by overactive immune cells that destroy the tissues of the body, such as psoriasis and multiple sclerosis.

Working with a research team led by Prof Luke O’Neill, a professor of biochemistry in Trinity’s School of Biochemistry and Immunology, the study’s lead author – Dr Stefano Angiari, who is a biochemistry research fellow – explored the role of PKM2 in the regulation of two cell types, Th17 and Th1.


In a press statement, Angiari said: “Th17 and Th1 cells are very important for the damage that happens in auto-immune diseases such as psoriasis and multiple sclerosis. We have found that interfering with PKM2 blocks these cells and limits inflammation.”

O’Neill added: “PKM2 is a fascinating protein that has a role in how cells use glucose for energy, but it also moonlights in the immune system, where we have found it can be especially troublesome. We are currently exploring it as a new target for therapies that might work in patients with diseases like psoriasis and multiple sclerosis, where treatment options are limited.”

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The research was sponsored by the EU Marie Curie programme, and the Wellcome Trust.

Last month, two Trinity researchers were among six recipients of a €25 million grant from Science Foundation Ireland to support new research infrastructure.

Prof Kingston Mills and Prof Mani Ramaswami, researchers based in the Trinity Institute of Neurosciences, will receive funding to support high-quality research activities and innovation in areas of strategic priority across a variety of disciplines.

Earlier this year, the presidents of all seven Irish universities called for a rethink on how research is funded in Ireland after the European Research Council granted Irish-based researchers only one of its 408 grants.

In a press statement, the chair of the Council of the Irish Universities Association and President of Dublin City University, Brian MacCraith, said that Ireland’s lack of funding grants from the European Research Council was “a clear warning signal that demands urgent attention from government and the funding agencies”.

“As an island economy on the western edge of Europe, it is imperative that we have a world-class university sector to compete effectively for international investment”, he said. “Research plays an integral role in maintaining a world-class system. We now have a highly regrettable situation where many of our top scientists and researchers are getting no national funding.”

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